PAT for Real-time Culture Monitoring and Closed-Loop Process Control hosted by BTEC

In this three-day, hands-on course, you will gain familiarity with and applied insight into the functionality of control equipment and instrumentation, and how to integrate Process Analytical Technology (PAT) into a model yeast fermentation for more advanced in-line monitoring and process control. Participants will work with traditional sensors, a PAT spectral sensor, and multivariate data analysis (MVDA) software, to monitor, model, and control a model process.

This course will give professionals with experience in fermentation an in-depth introduction to process instrumentation and its integration into a distributed control system. Professionals will learn how process information is communicated and used for different engineering controls, including PID control, split-range control, and cascade control within the DeltaV distributed control system. A Raman spectral sensor and PLS model will also be deployed for process monitoring and control to familiarize participants with implementing PAT in an upstream process. Participants will gain hands-on experience with data analytics software to build a data model for monitoring normally periodic, at-line measurements, in real-time to enable better control of those process parameters, and allow tighter control of the culture process. Coming out of this course professionals will have the knowledge of how to deploy a PAT system for an upstream process.